Objective To evaluate the knowledge, attitude, and practice towards fall prevention at home among cancer patients after chemotherapy, to explore the influencing factors of KAP. Methods A cross-sectional KAP survey on fall prevention at home was conducted among a convenient sample of 350 cancer patients after chemotherapy. Results The patients scored （62.86±15.13） in KAP totals, and （60.84±17.52）,（74.10±16.48）,（57.62±15.13） in knowledge, attitude, and practice domain respectively. The results of multiple linear regression analysis showed that patients′ education levels, family per capita income, medical expense payment schemes, family function, completed chemotherapy cycles, and whether medical staff made regular fall prevention follow-ups influenced KAP totals of post-chemotherapy patients （P＜0.05,P＜0.01）. Conclusion After chemotherapy, cancer patients have a more positive attitude to prevent falls at home, but they lack relevant knowledge and have poor behavioral compliance. In the future, attention should be paid to knowledge education about the risk factors of falls at home and ways to reduce injuries of fall. At the same time, medical staff should increase the frequency of regular follow-up services.