Objective To explore the effect of continuous nursing care assisted by "hospital-community-family" chain management under the model of medical collaboration alliance. Methods The continuing nursing service center was established.Model of medical collaboration alliance, continuous nursing care was carried out in the way of homogenized "hospital-community-family" chain ma-nagement which integrated nursing techniques, nursing talents′ dual-track output and multimedia two-way feedback.Before and after the practice, a knowledge, attitude and practice (KAP) survey on continuous nursing care among nurses from grassroot hospitals was conducted, and patients′ self-care ability and satisfaction were evaluated. Results KAP survey score among 167 nurses from grassroot hospitals saw significant improvement from baseline （P＜0.01）. Likewise patients′ self-care ability（P＜0.01）.Patients′ overall satisfaction with chain management assisted continuous nursing care scored （4.17±0.46） points. Conclusion Chain management assisted continuous nursing care under the model of medical collaboration alliance can promote the construction of medical alliance, improve service ability ofnurses from grassroot hospitals, improve patients′ self-care ability, provide multi-level medical services, and meet the needs of patients at different levels.