Objective To explore the implementation effect of intradialytic exercise program in maintenance hemodialysis patients. Methods The maintenance hemodialysis patients were randomized into an intervention group of 29 cases and a control group of 30 cases. The control group received routine hemodialysis care without intradialytic exercise, including monitoring vital signs, recording treatment parameters and health education, while the intervention group were additionally subjected to a self-designed intradialytic exercise program, including 40 minutes of aerobic exercise and 20 minutes of resistance exercise. The dialysis adequacy, mobility, inflammatory indicators and quality of life before the intervention and 6 months after the intervention between the two groups were collected and compared. Results Six months after the intervention, the dialysis adequacy, mobility, inflammatory indicators and physical health score of the intervention group were significantly better than those of the control group （P＜0.05，P＜0.01）. Conclusion Intradialytic exercise program in maintenance hemodialysis patients is beneficial to enhance their dialysis adequacy and mobility, improve their inflammatory indicators and physical health.