Objective To reduce the incidence of constipation by establishing process quality control indicators of constipation prevention for patients with acute myocardial infarction（AMI）. Methods A total of 439 AMI patients were divided into an intervention group of 218 patients, and a control group of 221 patients, as determined by the admission time.The control group received routine nursing measures against constipation, while the intervention group was subjected to nursing measures and quality control measures assisted with monitoring of such nursing quality control indicators as laxative drugs administration rate, constipation prevention knowledge education rate, abdominal massage rate, glycerin rectal use rate, low pressure enema rate. Results After the intervention, the above-mentioned rates in the intervention group were significantly higher, while the incidence rate of constipation were lower, than in the control group （P＜0.05,P＜0.01）. Conclusion Establishment and implement of process quality control indicators of constipation prevention, helps reduce the incidence rate of constipation and defecation-related complications in AMI patients.