Objective To investigate self-management level of patients with mild to moderate Parkinson′s disease, to analyze the influencing factors, and to provide reference for formulation of self-management enhancing strategies. Methods The Parkinson′s Disease Self-Management Questionnaire, Barthel Index, Chronic Disease Self-Management Study Measures, Social Support Scale, and the Non-Motor Symptom Scale were used to survey 207 patients with mild to moderate Parkinson′s disease. Results The total score of self-management for patients with mild to moderate Parkinson′s disease was （56.52±16.66） points. Patients′ self-management level was positively correlated with activity of daily living level, social support, and self-efficacy, while negatively correlated with non-motor symptoms. Multiple linear regression analysis showed that self-efficacy, activity of daily living, non-motor symptoms, and social support contributed to self-management of patients with Parkinson′s disease （P＜0.01 for all）. Conclusion The self-management level of patients with mild to moderate Parkinson′s disease needs to be improved, and is influenced by multiple factors. It is recommended to establish a systematic, and individualized management plan for patients with Parkinson′s disease, in bid to improve the quality of life of patients.