Objective To explore the effect of a remote platform used for follow-up management of patients with early gastric cancer treated by endoscopic submucosal dissection (ESD). Methods We developed a remote follow-up management platform and provided follow-ups for 66 patients through the platform (intervention group). The effect was compared with 221 patients who received telephone follow-ups (control group). Results The rate of first-time endoscopic reexamination and Helicobacter pylori eradication rate were significantly higher in the intervention group compared with the control group (P<0.05 for both). Most patients (96.97%) were satisfied or very satisfied with the platform. Conclusion The application of the remote follow-up management platform after ESD for early gastric cancer can enhance efficiency of follow-up management, as well as compliance and satisfaction of patients.