Objective To improve resilience and subjective well-being of nurses born in the 1990s and to alleviate their anxiety by utilizing positive psychology interventions. Methods A total of 173 nurses were randomized into a control group of 90 and an intervention group of 83. The control group was not given any interventions, while the intervention group received positive psychology interventions. Resilience, anxiety and subjective well-being were evaluated before and 6 months into the intervention. Results The intervention group had higher scores of resilience and subjective well-being, but lower anxiety score compared with the control group after the intervention (P<0.05, P<0.01). Conclusion Positive psychology interventions can promote resilience and subjective well-being and ameliorate anxiety of nurses born in the 1990s.