Objective To implement shared governance into medication administration and to improve the awareness and participation of nurses in medication safety management, thus to reduce potential medication errors and medication administration errors. Methods From July to December 2019, we implemented shared governance into medication administration to improve medication safety. The incidence of potential medication errors and medication administration errors, as well as nurses′ decisional involvement were compared with conventional management of medication administration in January to June 2019. Results The incidence rates of potential medication errors and medication administration errors were significantly decreased, whereas nurses′ decisional involvement and beliefs in medication safety were significantly improved after implementation of shared governance (P＜0.05, P<0.01). Conclusion Implementation of shared governance can effectively enhance nurses′ awareness of medication safety and reduce medication administration errors and potential medication errors.