Objective To identify factors associated with operating room nurses′ intention to report patient safety incidents in general hospitals, and to provide reference for nursing managers. Methods A total of 540 operating room nurses working in 4 general hospitals in Wuhan city were selected using convenience sampling and were surveyed in terms of their intention to report patient safety incidents, attitude towards patient safety, and barriers to incident reporting. Results The median score of intention to report patient safety incidents was 14 (P25-P75,11-15). Nurses′ intention to report was correlated with their perceptions of patient safety culture and barriers to incident reporting (P<0.01 for both). Multiple stepwise regression analysis showed that punitive culture, reporting process, feelings of management, work length and employment type were factors influencing nurses′ reporting intention （P＜0.05，P＜0.01）. Conclusion Nurses in operating room of general hospital had positive intention to report patient safety incidents and their reporting intention was affected by both system and personal factors. Nursing managers should improve the reporting and feedback process, cultivate non-punitive culture to enhance nurses′ intention to report.