Objective To summarize and evaluate the relevant evidence of interventions to prevent, delay or reverse frailty in the elderly, and to provide evidence-based reference for clinical practice. Methods Following the 6S Evidence Pyramid model, the relevant evidence of prevention, delaying or reversing frailty in the elderly were searched, including guideline, expert consensus, evidence summary and systematic review. Quality of the included literature was evaluated by two researchers, and the evidence was extracted and summarized. Results Sixteen publications including 4 guidelines, 1 expert consensus report, 2 evidence summary reports and 9 systematic reviews were eligible. Thirty pieces of evidence were summarized from 6 aspects: exercise intervention, nutrition intervention,multifactorial intervention,pharmaceutical administration, geriatric assessment and health education. Conclusion Evidence users should consider clinical environment and patients′ preferences to reasonably select evidence for transformation and application, thus to provide personalized interventions for the frail elderly.