Objective To explore the status of stigma and its influencing factors in female patients with infertility, and to provide re-ferences for intervention strategies for the population. Methods A self-designed general information questionnaire, the Infertility Stigma Scale, Self-Esteem Scale, Social Support Rating Scale, and Family APGAR index were used to investigate among 245 female patients with infertility. Results The total stigma score in female patients with infertility was (70.68±17.06) points.Traditional reproduction viewpoint, fertility stress, low self-esteem and willingness to disclose infertility had a predictive effect both on self-stigma and perceived stigma; self-stigma was also affected by women′s education levels, and social support; perceived stigma was additionally affected by family APGAR index （P＜0.05,P＜0.01）. Conclusion Stigma in female patients with infertility was at medium level.Strategies of improving educational opportunities, mitigating the impact of traditional reproduction viewpoint, improving social support and enhancing self-esteem of infertile women, are widely beneficial to reduce their stigma.