Objective To explore the effect of knowledge to action (KTA) framework-based health management on parents of children with bipolar Ⅱ disorder during the depressive episode. Methods A total of 80 parents of children with bipolar Ⅱ disorder du-ring the depressive episode were selected as the study participants and randomly divided into 2 groups of 40 cases each.The control group received the routine health management, while the intervention group received KTA framework-based health management.The negative emotions of the children and parents of the two groups were measured at baseline and 12 weeks after intervention; parents′ knowledge on bipolar Ⅱ disorder and skill mastery were measured at 12 weeks. Results After 12 weeks′ intervention, the standard scores of the Self-rating Anxiety Scale and the Self-rating Depression Scale in children and parents of the two groups were significantly lower than those of the baseline, with the intervention group saw a more significant drop from baseline （P＜0.01 for all）.After 12-week intervention, the score of disease-related knowledge, disease management techniques and requirements for return visits in the parents of the intervention group were significantly higher than those in the control group （P＜0.01 for all）. Conclusion KTA framework-based health management could improve the negative emotions of children and parents, effectively push parents to learn knowledge of bipolar disorder, and improve their management skills.