Objective To explore the effect of early mobilization program on ICU patients after liver transplantation. Methods A total of 40 patients after liver transplantation were divide into 2 groups according to the time sequence, with 20 cases in each group.The control group was given routine nursing care after liver transplantation, while the intervention group was additionally subjected to an expert-panel-discussion based early mobilization program for ICU patients after liver transplantation. Results The time to first-time postoperative gas passage, and the time to gastric tube removal in the intervention group were shorter than those in the control group （P＜0.01 for both）.The Barthel Index score and MRC-score measured at various time points had significant time effect, group effect, and group by time effect （P＜0.01 for all）.There was no case of abdominal bleeding or bile leakage in the two groups. Conclusion Early activities in ICU after liver transplantation can help patients restore gastrointestinal function early on, regain muscle strength, and improve activities of daily living.