Objective To explore the effects of precise blood pressure management in preventing cerebral hyperperfusion syndrome in postoperative Moyamoya patients. Methods A total of 212 patients with Moyamoya disease who received intracranial-extracranial vascular bypass (superficial temporal artery-middle cerebral artery) surgery were divided into 2 groups according to hospitalization periods.The control group (n=102) received routine neurosurgical nursing care for postoperative blood pressure management, while the intervention group (n=110) additionally received precise blood pressure management.The incidence rate of postoperative cerebral hyperperfusion syndrome was compared between the two groups. Results The incidence rate of cerebral hyperperfusion syndrome was 25.49% in the control group and 10.91% in the observation group.There was significant difference between the two groups (P＜0.01). Conclusion Precise blood pressure management reduces the incidence rate of cerebral hyperperfusion syndrome after extracranial-intracranial bypass surgery for Moyamoya disease, and plays an important role in recovery of patients.