Objective To design a nursing follow-up system for discharged patients with venous thromboembolism（VTE）, and to observe and evaluate its application effects. Methods We set up a research team, designed a structured follow-up checklist based on nursing process, built a health education knowledge base for discharged patients with VTE, and developed a structured nursing follow-up system based on the hospital information system.The system was officially put into use from January 2018, and the changes of various quality evaluation indicators and follow-up results during operation were observed. Results Up to June 2020, a total of 3 417 VTE patients (4 783 case times) were followed up using the system.The successful telephone follow-up rate of the discharged VTE patients was 96.78%. From 2018 to 2020, the 30-day readmission rate because of VTE decreased from 3.60% to 2.88%, and the medication compliance, medication information understanding and nursing service satisfaction among the patients increased year by year. Conclusion The structured nursing follow-up system designed based on nursing process can effectively improve follow-up quality and efficiency, and it can provide guarantee for high-quality, standardized and homogeneous follow-up se-rvices.