Objective To explore the application effect of Med-Match game in medication practice teaching for nursing students in cardiovascular department. Methods The grade four students in our nursing school were randomized into 2 affiliated hospitals for clinical practice by drawing lots, the 78 undergraduate nursing students practicing in the cardiovascular department of hospital A were taken as a control group, and another 75 undergraduate nursing students practicing in cardiovascular department of hospital B were regarded as an experimental group. The control group adopted traditional clinical practice teaching, while the experimental group additionally incorporated Med-Match game. The critical thinking ability and clinical practice skills of the two groups were evaluated at the first day and last day practicing in the cardiovascular department. Results The score of critical thinking ability and clinical practice skills of the experimental group were significantly better than those of the control group (P＜ 0.01 for all). Conclusion The integration of Med-Match game in the teaching of clinical medication practice makes an effective connection between theory, practice and clinical nursing, which can significantly improve the critical thinking ability and clinical practice ability of undergra-duate nursing students, and it is an effective way to cultivate applied nursing personnel.