Objective To understand the current status of health-promoting lifestyle among young and middle-aged high risk population of cardio-cerebrovascular events in enterprises, and to explore its influencing factors. Methods A total of 515 young and middle-aged high risk population of cardio-cerebrovascular events from enterprises in Lishui city were investigated using the Health Promotion Lifestyle Scale (HPLP-Ⅱ), the Health Behaviors Self-efficacy Scale and the Kessler Psychological Distress Scale. Results The HPLP-Ⅱ total score of the young and middle-aged high risk population of cardio-cerebrovascular events was (98.93±19.64). Multiple linear regression analysis showed that, self-efficacy, psychological distress, age, marital status and educational background were the influencing factors of their health-promoting lifestyle (P<0.05，P<0.01). Conclusion The health-promoting lifestyle among the young and middle-aged high risk population of cardio-cerebrovascular events in enterprises is at a medium level, community health caregivers should pay more attention to those younger high risk population with higher educational background and lower self-efficacy, unmarried and suffered from psychological distress，give them targeted intervention, so as to improve their health-promoting lifestyle.