Objective To explore the relationship between Palliative Performance Scale (PPS) score and the risk of death at 30 days and 90 days in advanced cancer patients, and to identify the reference value of PPS in hospice care practice. Methods The electronic medical records and follow-up records of 194 advanced cancer patients were retrospectively reviewed, the relationship between PPS score and patient survival time was assessed, and the main factors influencing patients′ risk of death at 30 days and 90 days were analyzed. Results The mean survival time of the whole study population was (33.5±1.6) days. The PPS score was moderately and positively correlated with survival time (r=0.643, P<0.01). The results of Kaplan-Meier survival curve of 30 days and 90 days stratified by PPS score showed that, there was significant difference among PPS score of 30%, 40%, 50% (Log-rank test, P＜0.05)，and PPS score of 10%，70% revealed relatively independence (Log-rank test, P＜0.05). Cox regression indicated that, PPS score, age and history of tumor surgery were the independent factors influencing the risk of death in advanced cancer patients at 30 days and 90 days. Conclusion PPS score is related to the survival time of patients with advanced cancer, and it can provide reference for hospice care practice.