Objective To translate, revise and validate the Spiritual Coping Questionnaire, so as to provide a tool assessing spirituality for patients with advanced cancer. Methods A Chinese Spiritual Coping Questionnaire was formed after translation, expert consultation, cultural adjustment and other steps, which was then used to investigate 442 advanced cancer patients from 3 grade three hospitals in Guangzhou city to test its reliability and validity. Results The final Chinese version of spiritual Coping Questionnaire was consisted of 26 items, 7 dimensions and 2 subscales：positive spiritual coping (person, society, environment, transcendent) and negative spiritual coping (person, society, transcendent). Its content validity was 0.933, the cumulative variance contribution rate of 7 common factors was 73.251%. Confirmatory factor analysis showed:χ2/df=1.982, CFI=0.926, IFI=0.927, TFI=0.910, RMSEA=0.067, RMR=0.047; the internal consistency of the subscale was 0.884 and 0.908, and the test-retest reliability was 0.933 and 0.938. Conclusion The Chinese version of Spiritual Coping Questionnaire has good reliability and validity, which can be used to measure the spiritual coping styles of advanced cancer patients in China. 