Objective To design and implement PICC informed consent mobile medical decision support program, so as to enhance patients′ willingness to participate in decision-making. Methods A total of 86 patients undergoing PICC chemotherapy in gynecolo-gical oncology department were randomized into an intervention group and a control group, with 43 patients in each group. The control group received conventional PICC informed consent, while the intervention group additionally used the mobile nursing information system to construct and implement PICC informed consent mobile medical decision aid program. Results The score of anxiety and depression in the intervention group were significantly lower than those in the control group, its degree of decision-making participation was significantly higher than that in the control group, and its total score and subscale scores of decision-making participation satisfaction were significantly higher than those in the control group (P<0.05, P<0.01). Conclusion The PICC informed consent mobile medical decision aid program provides accurate decision aid for gynecological tumor patients, alleviates their anxiety and depression during catheterization, and improves their actual degree of decision-making participation and satisfaction.