Objective The explore the effectiveness of perioperative resistance exercise on sarcopenia in patients with Crohn′s disease. Methods A total of 71 patients were randomized into 2 groups.The control group （n=36）received routine perioperative nursing measures, while the intervention group （n=35） additionally was subjected to perioperative resistance exercise.Outcomes included grip strength,skeletal muscle mass, body fat rate, postoperative recovery of gastrointestinal function and walking distance. Results After the intervention, differences in grip strength measured one day before the surgery and at discharge, and differences in skeletal muscle mass and body fat rate measured at discharge and at baseline, were significant (P＜0.01 for all). The walking distances within 1-3 days after surgery in the intervention group were superior to those in the control group （P＜0.01）.There was no significant difference in gas passage time after surgery between the groups （P＞0.05）. Conclusion Perioperative resistance exercise significantly increased postoperative grip strength of Crohn′s disease patients, reduced the attenuation degree of postoperative muscle mass, prevented postoperative body fat increase and promoted postoperative rehabilitation.