Objective To investigate the concordance of pediatric self and parent reports on quality of life of children with cancer aged 5-7 during hospitalization. Methods Convenient sampling method was used to select 105 dyads of children aged 5-7 and their parents.The survey instruments included a general information questionnaire, Pediatric Quality of Life Inventory TM Generic Core Module （PedsQL TM4.0, 5-7 years old children′s version）, and Pediatric Quality of Life Inventory TM Cancer Module （PedsQL TM3.0, 5-7 years old children′s version）. Results The children reported quality of life were discordant with parents′ report. There were 154 counts of parent-reported scores lower than children-reported scores, versus 53 counts of children-reported scores lower than parent-reported scores. Conclusion Self-reporting by cancer children aged 5-7 years is feasible, but there is discordance between parent and child reports.In clinical nursing practice, it is necessary to fully consider the possible factors affecting the concordance, appropriately utilize patient-reported outcomes to help children and families bring attention to the reaction from diseases and treatments.