Objective To explore the application value of pediatric assessment triangle in observing condition of children in the infusion room. Methods Children who received infusion treatment in the infusion room were evaluated by using pediatric assessment triangle and were classified into stable or unstable group according to their condition. Five hundred children in each group were selected and compared.Results There were significant differences in length of stay in the emergency room, hospitalization rate, rate of ICU admission, C-reactive protein value, and white blood cell counts between the two groups (P<0.01 for all). Conclusion Pediatric assessment triangle can be used to observe condition of children in the infusion room, thus to improve medical safety.