Objective To improve nutritional status and poor experience of radiochemotherapy in nasopharyngeal carcinoma patients undergoing concurrent radiochemotherapy. Methods Seventy-four nasopharyngeal carcinoma patients were divided into a control group of 36 and an intervention group of 38 according to their admission time. Patients of both groups underwent intensity-modulated radiotherapy with concurrent chemotherapy, as well as routine nursing care. The control group received conventional nutritional support, while their counterparts in the intervention group were subjected to nurse-led multidisciplinary nutritional support. The effect was evaluated at completion of the radiochemotherapy course (7 weeks). Results The PG-SGA score, Body Mass Index, total serum protein, albumin and hemoglobin in the intervention group were significantly better than those in the control group (P<0.05, P<0.01). The incidence of complications of radiochemotherapy and severe malnutrition in the intervention group were significantly lower than those in the control group (P<0.01 for all). Conclusion Nurse-led multidisciplinary nutritional support for patients with nasopharyngeal cancer undergoing concurrent radiochemotherapy, can improve nutritional status of patients and reduce adverse reactions.