Objective To improve the treatment effect of patients with anterior disc displacement without reduction of the temporomandibular joint (TMJ). Methods A total of 64 patients with anterior disc displacement without reduction of the TMJ were randomized into a control group of 31 and an training group of 33. Both groups received sodium hyaluronic acid for injection. The control group was given routine nursing care, while their counterparts in the training group were addtionally subjected to orofacial myofunctional therapy. The effect was evaluated after 3 months. Results The training group had lower pain score and greater mouth opening compared with the control group after the intervention (P<0.01 for both). Negative emotions in both groups were within normal range and showed no significant differences between the two groups （P>0.05 for all）. Conclusion Adding orofacial myofunctional therapy in patients with anterior disc displacement without reduction of the TMJ underwent sodium hyaluronic acid for injection, can effectively relieve pain and increase mouth opening.