Objective To explore the role of nurse caring team in an infectious disease epidemic and to provide reference for nursing management. Methods The nurse caring team well played the role in providing caring for first-line nurses during on-call period, working period and quarantine period in an infectious disease epidemic. The number of front-line nurses′ feedbacks of problems was calculated. Results Under the initiative of the nursing department, 160 head nurses provided caring for first-line nurses, and about 600 nurses received caring from the nurse caring team per day. Feedbacks of the first-line nurses were related to daily life, physical, work-related and psychological problems, and were decreased after running the nurse caring team. Conclusion Motivating the nurse caring team to practice caring for the first-line nurses plays an important role in prevention and control of infectious disease epidermic.