Objective To identify the risk factors of femoral artery complications after the use of the Angio-Seal arterial puncture closure device (APCD) and to establish a prediction model, so as to provide reference for clinical nursing. Methods A sample of 611 patients undergoing transfemoral catheterization and using Angio-Seal APCD were enrolled. The risk factors of femoral artery complications were analyzed by univariate and multivariate logistic regression, and the risk prediction model was established for verification. Results Body Mass Index, use of low-molecular-weight heparin, sheath size, activated clotting timeand immobilization time were risk factors of vascular complications occurred following Angio-Seal deployment(OR 2.087-14.005;P＜0.05,P＜0.01). The area under ROC curve of this model was 0.864, with the sensitivity of 72.7% and the specificity of 88.2%. Decision curve analysis showed that the prediction of bleeding risk in the range of 0.02-0.81 had clinical effect. Conclusion Risk factors of femoral artery complications using Angio-Seal APCD were high BMI and short immobilization time, etc. The risk prediction model was effective and could be used as a reference for nursing practice.