Objective To improve the teaching effect of Health Assessment course. Methods A class of 110 nursing students of Grade 2017 were treated as the control group and given routine teaching, while their counterparts (a class of 110 nursing students of Grade 2018) were served as the intervention group and received face-to-face, online blended teaching modality, including building the teaching team,designing the course, refining the teaching difficulties and emphasis, and implementing online and offline blended teaching. Results The intervention group had significantly higher scores of performance in final examinations and self-directed learning ability compared with the control group (P<0.01 for all). All students in the intervention group gained excellent performance in online examination.Conclusion Face-to-face, online blended teaching modality can enhance the teaching effect.