Objective To define the norms of the clinical Nurse Innovation Ability Scale (NIAS) in Grade-A tertiary general hospital in Hubei Province, and to provide references for evaluation of nurse innovation ability. Methods A total of 2485 nurses from 56 grade-A tertiary general hospitals in 12 cities of Hubei province were selected by proportional and stratified sampling，then they were investigated using the Clinical Nurse Innovative Ability Evaluation Scale, and the corresponding norm, classification norm, percentile norm and delimitation norm were defined according to the characteristics of clinical nurses′ innovation ability score. Results The total score of the corresponding norm of NIAS was (139.83±20.26), the subscale corresponding norm of innovation subject was (58.73±8.79), innovation process was (41.27±7.21), innovation environment and pressure was (28.28±5.45), innovation product was (11.55±5.01). According to the differences in characteristics, the classification norms for different gender, age, marital status, educational background, working years and professional title were formed, the percentile norm was established by dividing the total score of NIAS and the score of each dimension by 5% percentile. The delimitation norm of clinical nurses′ innovation ability:＜115 was classified as very poor, 115 to less than 129 was poor, 129 to less than 150 was general,150-168 was good, and more than 168 was excellent. Conclusion The defined corresponding norm, classification norm, percentile norm and delimitation norm of the Clinical Nurse Innovation Ability Scale for clinical nurses in grade A tertiary general hospital in Hubei Province can provide a theoretical guidance basis for accurate evaluation of the innovation ability of clinical nurses.