Objective To understand the status of anticipatory grief among spouses of patients with recurrent cervical cancer, and analyze factors that affect its level，so as to provide reference for the development of targeted psychological interventions. Methods Totally, 206 spouses of patients with recurrent cervical cancer were investigated by using the demographic data questionnaire, the Anticipatory Grief Scale, Chinese version of the Post-traumatic Growth Inventory and the Distress Disclosure Index. Then the influencing factors of anticipatory grief were analyzed.Results Anticipatory grief in spouses of patients with recurrent cervical cancer was (89.87±12.78) points. Regression results showed that recurrence site, therapy-free interval, treatment regimen, duration of marriage, and self-disclosure, and post-traumatic growth affected anticipatory grief (P<0.05,P<0.01). Conclusion Anticipatory grief in spouses of patients with recurrent cervical cancer is serious, which can be reduced by improving the level of self-disclosure and post-traumatic growth.