Objective To explore the clinical effect of individualized self-management intervention for convalescent stroke survivors. Methods Totally, 80 stroke patients at recovery stage were recruited and randomly divided into an intervention group (n=40) and a control group (n=40) by using random number table method. The control group was given conventional nursing care and health education, while the intervention group additionally received individualized self-management intervention. The stroke prevention related knowledge level, rehabilitation self-efficacy and self-management behavior scores were measured 20 days, 3 months, and 6 months after the intervention. Results The group effect, time effect and group by time effect were significant for stroke prevention related knowledge level, rehabilitation self-efficacy and self-management behavior scores between the 2 groups （P＜0.01 for all）, and the outcomes in the intervention group were better than the controls. Conclusion Individualized self-management intervention can significantly improve stroke prevention related knowledge level, rehabilitation self-efficacy and the self-management behaviors of stroke survivors.