Objective To construct and implement a case manager-led pulmonary rehabilitation outpatient clinic, and to provide refe-rence for the whole-course pulmonary rehabilitation management of COPD patients. Methods A case manager-led multidisciplinary team including respiratory physicians, psychological counselors, nutritionists and rehabilitation therapists was built and provided whole-course pulmonary rehabilitation for 106 COPD patients attending a pulmonary rehabilitation clinic. Parameters of pulmonary function were assessed at admission, before discharge and 3 months after discharge and locus of control at admission and before discharge was also evaluated. Results Significant differences in pulmonary function indexes were found at different time points （P＜0.01 for all）.The score of internal health locus of control was significantly higher before discharge than that at admission, whereas the scores of powerful others health locus of control and chance health locus of control were significantly lower before discharge compared with baseline values at admission （P＜0.01 for all）. Conclusion Case manager-led whole-course pulmonary rehabilitation in pulmonary rehabilitation clinic can standardize pulmonary rehabilitation practices for COPD patients, improve their pulmonary function and locus of control, thus to enhance care outcomes and patients′ quality of life.