Objective To explore the effect of a whole-process health management program led by brain-heart health care manager on blood lipid level and stroke recurrence in patients with acute ischemic stroke (AIS). Methods A total of 189 AIS patients were divi-ded into a control group of 95 and an intervention group of 94 according to their admission time, receiving either conventional nur-sing care or brain-heart health care manager-led whole-process health management respectively. The anxiety and depression scores, blood lipid levels, therapeutic compliance, and stroke recurrence rate within 1 year after discharge were compared between the two groups. Results The intervention group had lower anxiety and depression scores, lower levels of total cholesterol, triglyceride and low-density lipoprotein cholesterol, higher therapeutic compliance and lower rate of stroke recurrence compared to the control group (P＜0.05,P＜0.01). Conclusion The brain-heart health care manager-led whole-process health management program for AIS patients can facilitate recovery, reduce recurrence and alleviate negative emotions.