Objective To investigate the effect of micro-teaching videos applied in health education for family caregivers of patients with pressure injury (PI). Methods Seventy-three family caregivers of patients with PI were randomly divided into a control group (n=36) and an intervention group (n=37), receiving either conventional health education or recorded micro-teaching videos for health education, respectively. Knowledge, behavior and self-efficacy of PI in family caregivers were evaluated before and after the intervention. The Braden scale was employed to assess risk factors of PI in patients and the DESIGN-R scale was used to evaluate healing state of the wounds. Results Caregivers in the intervention group had higher levels of knowledge, behavior and self-efficacy compared with the control group; and the Braden scale score was significantly lower, whereas wound healing was significantly better in the intervention group compared with the control group (P＜0.01 for all). Conclusion Use of micro-teaching videos in health education for family caregivers enhances their cognitive and behavioral levels of PI as well as self-efficacy; and reduces risk factors of PI in patients and improves wound healing.