Objective To investigate the current status of how nurses working in comprehensive hospitals implement restraint reduction strategies, and to explore the factors influencing nurses′ implementation. Methods A total of 434 nurses from five general hospitals were recruited and surveyed using a general information questionnaire and a self-designed questionnaire of Restraint Reduction Strategies Implementation by Nurses. Results The nurses scored （133.53±18.40） points in restraint reduction strategies implementation. Multiple linear regression analysis showed such factors as "understanding the definition and content of physical restraint", "recognition of the importance of reducing physical restraint strategies in hospitalized patients" and "length of service" influenced nurses′implementation of restraint reduction strategies (P<0.01 for all). Conclusion The nurses′ implementation of restraint reduction strategies was above median level. Attention should be paid to the training of nurses at different levels, so as to minimize physical restraints of patients while keeping them safe.