Objective To prevent pressure injury in the head among patients under general anesthesia with a prone position head support device. Methods A prone position head support device was invented and applied to 3 515 patients(the intervention group) under general anesthesia for spine surgery. Another 3 604 patients who used conventional gel pad for head protection in the same kind of surgery were seen as the control group. Incidence rate of intraoperative pressure injury between the 2 groups were compared. Results The intervention group had significantly lower incidence rate of intraoperative pressure injury than the control group (P＜0.05). Conclusion The application of a prone position head support device to patients under general anesthesia for prone position surgery can lower incidence rate of intraoperative pressure injury.