Objective To explore the impact of acceptance and commitment therapy (ACT) on behavioral problems in children with cerebral palsy and parental anxiety, depression and psychological flexibility in parents. Methods Sixty parents of children with cerebral palsy who had anxiety or depression were randomly divided into a control group and an intervention group of 30, receiving either routine nursing or ACT. The Self-rating Anxiety Scale (SAS), Self-rating Depression Scale (SDS), Parental Psychological Flexibility Questionnaire (PPFQ) and Child Behavior Rating Scale (CBRS) were used to evaluate the effect before and 8 weeks after the intervention. Results After 8-week intervention, the scores of the CBRS, SAS and SDS were significantly lower, whereas the PPFQ score was significantly higher in the intervention group compared to the control group （P＜0.05,P＜0.01）. Conclusion ACT can alleviate anxiety and depression of parents of children with cerebral palsy, and improve their parental psychological flexibility, thus to decrease their children′s behavioral problem.