Objective To explore the influential factors and successful experience of core authors in nursing research in large general hospitals through qualitative research, in order to provide reference for improving nursing research level and advancing development of nursing profession. Methods Ten core authors in nursing research received in-depth interviews concerning influencing factors of scientific research activities and successful experiences. Data were transcribed and analyzed. Results Three themes of research experience were identified: motivation of nursing research included interest and passion; barriers to nursing research were intrinsic (inadequate research ability due to low educational background) and extrinsic (lack of time and energy, shortage of research conditions and external support); and successful experience (critical thinking during work, efficiently read the literature, actively participate in learning, be good at utilizing support, create research culture and emphasize research monitoring and guidance). Conclusion Core nursing authors in large general hospitals have positive cognition of nursing research and paper writing, but they face many intrinsic and extrinsic barriers to nursing research. Successful experience plays an important role in their research.