Objective To explore a new model for patient safety management and to ensure patient safety. Methods We constructed and implemented a triad for patient safety management project, then evaluated the effect using the Hospital Survey on Patient Safety Culture (HSOPSC), adverse nursing events, and nursing-sensitive quality indicators. Results The scores of 10 dimensions of HSOPSC except organizational learning-continuous improvement and staffing were significantly enhanced after the intervention (P＜0.05,P＜0.01). The incidence of adverse nursing events and 3 nursing-sensitive quality indicators decreased since 2016. Twenty-eight safety management projects and 51 safety-related quality control circle activities were conducted, as well as 45 papers reporting safety management experience were published. Conclusion Implementation of the triad for patient safety management project can effectively improve nurses′ awareness of patient safety culture, reduce the incidence of adverse events and ensure patient safety.