Objective To investigate the status of postoperative kinesiophobia in breast cancer patients and to analyze its influencing factors. Methods A total of 180 postoperative breast cancer patients were selected and investigated with a demographic questionnaire, the Tampa Scale of Kinesiophobia, the Simplified Coping Style Questionnaire (SCSQ), the Visual Analogue Scale, and the Self-rating Anxiety Scale. Results The breast cancer patients (36.23±5.28) points in kinesiophobia, with 50 cases (29.59%) being found to have kinesiophobia.Multiple linear regression analysis showed that education levels, household monthly income per person, whether having had lymph node dissection, active coping scores, pain scores and anxiety scores were the influencing factors of postoperative kinesiophobia in breast cancer patients.All these factors could explain 38.30% of the total variation of kinesiophobia. Conclusion The incidence of postoperative kinesiophobia in breast cancer patients is high, which should arouse the attention of me-dical staff.Targeted intervention measures should be taken to help patients reduce the level of postoperative kinesiophobia, so that patients can carry out early functional exercise and speed up physical recovery.