Abstract:Objective To explore the target sites for improving bladder function in rat model of neurologic bladder after spinal cord injury (SCI) by employing ginger-partitioned moxibustion, and to provide a theoretical basis for clinical intervention. Methods Sprague-Dawley (SD) rat model of T10 SCI was developed through modified Allen′s method, then those met diagnosis of neurologic bladder after SCI were treated as the model group and the ginger-partitioned moxibustion group, with 10 rats in each group. Ten rats receiving removal of the T10 lamina without damage of the spinal cord were treated as the sham group. All rats in the 3 groups received anti-infection treatment, wound care and Crede manoeuvre. Meanwhile, the ginger-partitioned moxibustion group was given indirect moxibustion using ginger once a day, 10 min for each acupoint at day 1 postoperatively for 12 consecutive days. Results After treatment, the expression levels of P2X3 receptor, M2- and M3- muscarinic acetylcholine receptor mRNAs in the ginger-partitioned moxibustion group were significantly higher than those in the model group (P<0.05 for all). Conclusion Ginger-partitioned moxibustion could improve the expression levels of P2X3 receptor in spinal ganglion, M2- and M3- muscarinic acetylcholine receptor mRNAs in the urinary bladder tissue of rats with SCI, so as to ameliorate bladder function.