Objective To explore the effects of mindfulness meditation intervention on the experiences and hope level of nurses as the second victims. Methods A total of 46 nurses who experienced adverse events in the past 6 months were selected conveniently for mindfulness meditation intervention, which included 4 course modules, namely, mindfulness meditation introduction, mindfulness meditation framework, longitudinal guidance meditation plan, mindfulness meditation inquiry and reflection lasting 8 weeks. The Second Victim Experience and Support Tool (SVSET) and the Herth Hope Index (HHI) were used to evaluate the experiences and hope level of nurses as second victims before and after the intervention. Results After the intervention, except the dimension score of non-work-related support, the total SVSET scores and its other subscale scores of the nurses as second victims were significantly lower than those before the intervention, while the total scores and each dimension scores of HHI were significantly higher than those before the intervention (P<0.01 for all). Conclusion Mindfulness meditation intervention is suitable for the second victim population of nurses, which can effectively reduce their painful experiences after going through adverse events, enhance their support and hope level, and improve nurses′ mental and physical health.