Objective To explore the status of and risk factors for frailty in elderly patients with acute myocardial infarction （AMI） receiving percutaneous coronary intervention （PCI）, and to provide reference for early screening and prevention of frailty. Methods A total of 158 elderly AMI patients receiving elective PCI in the department of cardiology were assessed using the Fried Frailty Phenotype Scale before the surgery, then risk factors were identified through univariate analysis and Logistic regression analysis. Results Forty-four patients （27.85%）developed frailty. There were significant differences in physical, psychological and cardiac function between frailty and non-frailty patients, and advanced age, long-term use of multiple medications, Charlson Comorbidity Index score, impairment of activities of daily living, IcTnI were risk factors for frailty in elderly AMI patients （P＜0.05）. Conclusion The prevalence of frailty in elderly AMI patients was high and affected by multiple factors. Preventive measures should be developed by considering physical, psychological and laboratory indexes of the patients.