Objective To determine the level and factors associated with adherence to fluid restrictions among patients who underwent home peritoneal dialysis. Methods A total of 167 patients undergoing home peritoneal dialysis were investigated in terms of their adherence to fluid restrictions and the impact of demographic data on adherence to fluid restrictions was analyzed. Semi-structured interviews were conducted on 15 patients to identify the causes of non-adherence, then data were analyzed using content analysis. Results Two-thirds of patients (66.5%) were adherent to fluid restrictions, while 33.5% of them reported poor level of adherence.Logistic regression analysis showed that gender, age and duration of peritoneal dialysis were factors associated with adherence to fluid restrictions （P＜0.05,P＜0.01）.The reasons for poor adherence could be summarized into 5 themes: unawareness of fluid restrictions,negative attitude, having trouble or difficulty in fluid intake volume calculation, negative feelings,and objective factors. Conclusion Adherence to fluid restrictions in peritoneal dialysis patients needs to be enhanced and is affected by multiple factors.Targeted intervention should be provided to improve their adherence.