Objective To investigate the psychological stress status and its influencing factors among inpatients with Coronavirus Di-sease 2019 (COVID-19), and to provide reference for conducting psychological crisis intervention. Methods A total of 652 inpatients with COVID-19 were selected using convenient sampling, then their psychological stress symptoms were investigated using 4 factors (somatization, depression, anxiety, sleep and dietary conditions） of the Symptom Checklist 90 （SCL-90）, and the Cognitive Fusion Questionnaire and the Medical Coping Modes Questionnaire were used to investigate their coping style. Results The score of somatization, depression, anxiety, sleep and dietary conditions factors was 1.70±0.53, 1.58±0.57, 1.53±0.60, and 1.81±0.60 respectively, and a total of 172（26.38%） patients experienced somatization symptom, 117（17.94%） suffered from anxiety, 124（19.02%） suffered from depression, and 236（36.20%） suffered from sleep and eating disorders. Gender, marital status, age, degree of cognitive fusion and coping modes of the disease were the influencing factors of somatization, depression, anxiety, and sleep and dietary conditions for the inpatients with COVID-19 （P＜0.05,P＜0.01 ）. Conclusion The inpatients with COVID-19 experience psychological stress symptoms to some extent. Medical staff should strengthen psychological intervention for those COVID-19 patients who are middle-aged or elderly, female, divorced or widowed, and with a high degree of cognitive fusion, so as to help them hold a correct attitude towards the disease, adopt a proper disease coping style, then to improve their physical and mental health.