Objective To construct a rehabilitation management process for Post-stroke Dysphagia (PSD), and to explore its application effects. Methods A rehabilitation management process for PSD was constructed via evidences searching and expert consultation. Then totally 411 first stroke patients were divided into a control group (n=198) and an intervention group (n=213) chronologically, the control group was cared using the routine rehabilitation nursing process, while the intervention group was treated using the rehabilitation management process, including PSD screening, PSD severity determination, food intaking risk assessment, rehabilitation intervention and dynamic assessment. Results The rehabilitation intervention time in the intervention group was statistically shorter than that of the control group (P＜0.01); at admission and one month after stroke attack, there was no significant difference in the incidence of PSD between the two groups (P＞0.05), at one month after stroke attack, the PSD severity and quality of life in the intervention group were significantly better than those in the control group (P＜0.01 for both). Conclusion Application of the rehabilitation management process for PSD could effectively shorten the rehabilitation intervention time for stroke patients, alleviate their severity of dysphagia, and improve their quality of life.