Objective To construct a network-based regional infrared radiation management model, and to evaluate its effectiveness in home care of elderly patients at high risk of pressure ulcer. Methods By convenience sampling, 85 home bound elderly patients at high risk of pressure ulcer were recruited and randomly divided into a control group (n=43), and an intervention group (n=42). The control group was given discharge guidance and follow-up according to the nursing routine, while the intervention group was treated with the network-based regional infrared radiation management model in which, workflows of assessment, service, and consultation service were specified. After 4 months, the incidence rate of pressure ulcer, quality of pressure ulcer care and patient satisfaction in the two groups were compared. Results The incidence rate of pressure ulcer was significantly lower, the quality of pressure ulcer care and patient satisfaction were significantly higher in the intervention than in the control group （P<0.05，P<0.01）. Conclusion The establishment of network-based regional infrared radiation management in home care of elderly patients at high risk of pressure ulcer has formed a scientific and standardized management system for pressure ulcer of discharged patients, improved the quality of home care and management level of pressure ulcer, and improved patient satisfaction.