Objective To evaluate the safety and effect of postoperative early off-bed activities on patients receiving posterior correction and fusion surgery for scoliosis. Methods A total of 60 patients were enrolled and divided into 2 groups: the intervention group (30 cases from June 1st 2019 to September 30th 2019) were instructed to do off-bed activities within 24-72 postoperative hours and prior to wound drainage removal, while the control group (30 cases from June 1st 2018 to September 30th 2018) were instructed to do off-bed activities only after full removal of wound drainage tube. The safety related outcomes (the volume and duration of wound drainage, volume of total blood loss, hemoglobin level before discharge), and effect measures (the time to start off-bed activities after surgery, and hospital stays after surgery，indwelling time of the drainage tube), were compared between the two groups. Results The time to start off-bed activities and postoperative hospital stays in the intervention group were significantly shorter than those in the control group (P＜0.05, P＜0.01). No significant differences were found in the volume and duration of wound drainage, volume of total blood loss, hemoglobin level before discharge and indwelling time of the drainage tube between the two groups (P＞0.05 for all). Conclusion Early off-bed activities within 24-72 postoperative hours and prior to wound drainage removal can help to decrease the hospital stay of patients receiving posterior correction and fusion surgeries for scoliosis without increasing the risk of postoperative blood loss.