Objective To investigate the effect of a perioperative voiding nursing workflow in patients with ischemic stroke. Methods A total of 394 patients were divided into a control group (n=206) and an intervention group (n=188) according to the admission dates. The control group received routine interventional-therapy based voiding nursing care, while the intervention group was subjected to a perioperative voiding nursing workflow which was built based on expert consultation. Perioperative voiding, and blood pressure changes before and after first postoperative voluntary voiding (or voiding through a urinary catheter) were compared between the 2 groups. Results The incidence rates of urinary retention in the intervention group before and after surgery were significantly lower than those in the control group (P<0.01 for all). The increase of systolic and diastolic blood pressure in the intervention group was significantly smaller than that in the control group (P<0.05,P<0.01). Conclusion Perioperative voiding nursing workflow can alleviate perioperative in-bed voiding difficulty of patients, effectively prevent urinary retention, and help to maintain the stability of postoperative blood pressure.