Objective To construct an intervention program for discharge preparation services (DPS) for colorectal cancer patients undergoing laparoscopic surgery and to explore the effects of the intervention program. Methods An DPS intervention program was made based on literature review, survey study, and Individual and Family Self-management Theory, and Transitions Theory. Cluster sampling method was used to recruit colorectal cancer patients undergoing laparoscopic surgery, and the patients were divided based on the unit they were admitted into a control group (n=56), who received perioperative care and routine discharge teaching, and an intervention group (n=60), who additionally received DPS in pursuant to the DPS intervention program. Results There were significant differences in total score of readiness for hospital discharge, total score of the quality of discharge teaching, the severity degree of complications and unplanned readmission rate at 4 weeks after surgery between the two groups (P<0.05, P<0.01). Conclusion The DPS program can improve the quality of discharge teaching by nurses and patients′readiness for hospital discharge, and reduce complication rate and unplanned readmission rate.